It neutrophils followed by bone marrow-derived stromal cells at 21 days in

It neutrophils followed by bone marrow-derived stromal cells at 21 days in a PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/15957913 skeletally aged rabbit model of cartilage repair. Three chitosan implant formulations reproducibly elicited neutrophils which guided osteoclasts to the bone plate, delayed deposition of collagen and glycosaminoglycan, induced subchondral bone resorption and repair and improved integration of the repair tissue with 4-((2-Hydroxyethyl)(methyl)amino)benzaldehyde the subchondral bone. In contrast, in control defects, osteoclasts did not migrate to the bone plate, bone remodeling was limited to new woven bone at the base of the hole and stromal cells that migrated into the control drill holes promptly differentiated into chondrocytes and fibroblasts (col I-rich fibrocartilage).Lafantaisie-Favreau et al. BMC Musculoskeletal Disorders 2013, 14:27 http://www.biomedcentral.com/1471-2474/14/Page 15 ofand BioSyntech Inc. (now Piramal Healthcare Canada Inc., JS). Data in this paper were generated towards the M.Sc. thesis of CHLF ( ole Polytechnique), and were presented in part at the International Cartilage Repair Society (2010, Sitges, Spain) and the Orthopaedic Research Society (2012, San Francisco, USA). Author details 1 Institute of Biomedical Engineering, ole Polytechnique, C.P. 6079 succ. Centre-Ville, Montr l, QC H3C 3A7, Canada. 2Department of Chemical Engineering, ole Polytechnique, C.P. 6079 succ. Centre-Ville, Montr l, QC H3C 3A7, Canada. 3Biosyntech/Piramal HealthCare Canada Inc, 475 Armand Frappier, Laval, QC H7V 4B3, Canada. 4Current address: Comparative Orthopaedic Research Lab, Department of Clinical Studies, University of Guelph, 50 McGilvray, Lane Guelph, ON N1G 2W1, Canada. 5The Research Institute of the McGill University Health Centre, Montreal General Hospital, 1650 Cedar Ave, Montr l, QC H3G 1A4, Canada. 6Orthopaedic and Sport Medicine Clinic of Nova Scotia, Dalhousie University, 5595 Fenwick St., Suite 311, Halifax, NS B3H 4M2, Canada. Received: 4 July 2012 Accepted: 23 December 2012 Published: 16 January PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/14704548 2013 References 1. Breinan HA, Martin SD, Hsu HP, Spector M: Healing of canine articular cartilage defects treated with microfracture, a type-II collagen matrix, or cultured autologous chondrocytes. J Orthop Res 2000, 18:781?89. 2. Knutsen G, Drogset JO, Engebretsen L, Grontvedt T, Isaksen V, Ludvigsen TC, Roberts S, Solheim E, Strand T, Johansen O: A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. J Bone Joint Surg Am 2007, 89:2105?112. 3. Toyokawa N, Fujioka H, Kokubu T, Nagura I, Inui A, Sakata R, Satake M, Kaneko H, Kurosaka M: Electrospun synthetic polymer scaffold for cartilage repair without cultured cells in an animal model. Arthroscopy 2010, 26:375?83. 4. Carmont 1-(4-Bromo-2-pyridyl)piperazine MR, Carey-Smith R, Saithna A, Dhillon M, Thompson P, Spalding T: Delayed incorporation of a TruFit plug: perseverance is recommended. Arthroscopy 2009, 25:810?14. 5. Barber FA, Dockery WD: A computed tomography scan assessment of synthetic multiphase polymer scaffolds used for osteochondral defect repair. Arthroscopy 2011, 27:60?4. 6. Streitparth F, Schottle P, Schlichting K, Schell H, Fischbach F, Denecke T, Duda GN, Schroder RJ: Osteochondral defect repair after implantation of biodegradable scaffolds: indirect magnetic resonance arthrography and histopathologic correlation. Acta Radiol 2009, 50:765?74. 7. Hoemann CD, Sun J, Legare A, McKee MD, Buschmann MD: Tissue engineering of cartilage using an injectable and adhesive chitosanbased cell-delivery vehicle. Osteoa.